Naturopathic health

Ginger Zingiber Officinale Research

Ginger root health benefits Ginger has a long tradition of being very effective in alleviating symptoms of gastrointestinal distress and reducing intestinal gas. Reviews such as Borelli et al (2005) of six double-blind, randomized controlled trials with a total of 675 participants, have demonstrated that Ginger can be as effective as over the counter drugs for the control of nausea in pregnant women. Modern research has revealed that ginger possesses numerous therapeutic properties including immune boosting, antioxidant effects, an ability to inhibit the formation of inflammatory compounds, and direct anti-inflammatory effects. A number of studies including Altman R, Visalyaputra,S and Bone ME have demonstrated ginger root’s effectiveness as a painkiller / anti inflammatory with the Altman study demonstrating the benefits for osteoarthritis sufferers Gingerols, the main active components in ginger and the ones responsible for its distinctive flavor, may also inhibit the growth of human colorectal cancer cells, according to Dr Ann Bode of the University of Minnesota's Hormel Institute although human studies are yet to confirm that. Research demonstrating ginger's immune boosting and antioxidant properties: Textbooks etc. - The Ayurvedic Pharmacopoeia of India Pt.1/103, 2/12 - Database on Medicinal Plants Used in Ayurveda, Vol. 5/316 - Ayurvedic Pharmacology: Gogte p.314 - Major Herbs of Ayurveda: Dabur/Williamson p.329 Ayurvedic Medicine: Pole p.183 Animal studies - Food Chem Toxicol. 2007 Jun;45(6):921-7. Epub 2006 Nov 29. Zingiber officinale Roscoe alone and in combination with alpha-tocopherol protect the kidney against cisplatin-induced acute renal failure. Ajith TA, Nivitha V, Usha S. - Phytother Res. 2006 Nov;20(11):997-1002. Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats. Yemitan OK, Izegbu MC. - Pharmacol Biochem Behav. 2006 Jun;84(2):179-88. Epub 2006 Jun 21. Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner. Haksar A, Sharma A, Chawla R, Kumar R, Arora R, Singh S, Prasad J, Gupta M, Tripathi RP, Arora MP, Islam F, Sharma RK. - Cancer Biother Radiopharm. 2004 Aug;19(4):422-35. Ginger (Zingiber officinale Rosc.), a dietary supplement, protects mice against radiation-induced lethality: mechanism of action. Jagetia G, Baliga M, Venkatesh P. - Prostaglandins, Leukotrienes and Essential Fatty Acids. Volume 67, Issue 6, December 2002, Pages 475-478. The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. M.Thomson, K. K. Al-Qattan, S. M. Al-Sawan, M. A. Alnaqeeb, I. Khan and M. Ali - East Afr Med J. 2002 Nov;79(11):588-92. Antibacterial effect of Zingiber officinale and Garcinia kola on respiratory tract pathogens. Akoachere JF, Ndip RN, Chenwi EB, Ndip LM, Njock TE, Anong DN. In vitro studies - Am J Chin Med. 2006;34(1):157-69. Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus. Imanishi N, Andoh T, Mantani N, Sakai S, Terasawa K, Shimada Y, Sato M, Katada Y, Ueda K, Ochiai H. - Food Chemistry . Volume 102, Issue 3, 2007, Pages 764-770. Stoilova, A. Krastanov, A. Stoyanova, P. Denev and S. Gargova - Arch Pharm Res. 2005 May;28(5):518-28. Isolation of a natural antioxidant, dehydrozingerone from Zingiber officinale and synthesis of its analogues for recognition of effective antioxidant and antityrosinase agents. Kuo PC, Damu AG, Cherng CY, Jeng JF, Teng CM, Lee EJ, Wu TS. Research showing ginger's benefits for osteoarthritis sufferers and as a painkiller / anti-inflammatory Textbooks etc. - Bhavaprakash/Sitaram B. p.136 - The Ayurvedic Pharmacopoeia of India Pt. 1/103, 2/12 - Database on Medicinal Plants Used in Ayurveda, Vol. 5/316 - WHO monographs Vol. 1 /277 - BHMA Guide p.110 - Ayurvedic Pharmacology: Gogte p.314 - Major Herbs of Ayurveda: Dabur/Williamson p.329 - Herbal Medicines: Newall/Anderson/Phillipson p.135 - Ayurvedic Medicine: Pole p.183 Review - Ann N Y Acad Sci. 2005 Nov;1056:206-17.Curcumin: getting back to the roots. Shishodia S, Sethi G, Aggarwal BB. Human studies - Altman RD et al Effects of a ginger extract on knee pain in patients with osteoarthritis Arthritis & Rheumatism, Volume 44, Issue 11 , Pages 2531 – 2538 - Bliddal H, Rosetzsky A, Schlichting P, Weidner MS, Andersen LA, Ibfelt HH, et al. A randomized, placebo-controlled, cross-over study of ginger extracts and ibuprofen in osteoarthritis. Osteoarthritis Cartilage 2000;8:9-12. - Bone M E et Al Ginger root—a new antiemetic The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery Anaesthesia Volume 45 Issue 8 Page 669-671, August 1990 - Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses 1992;39:342-8. 1992 - Srivastava KC, Mustafa T. Ginger (Zingiber officinale) and rheumatic disorders. Med Hypothesis 29 (1989):25-28 1989. Wigler I, Grotto I, Caspi D, Yaron M. The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis. Osteoarthritis Cartilage. 2003 Nov;11(11):783-9. - Visalyaputra,S et al The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy. Anaesthesia. 53(5):506-510, May 1998. Animal studies - Phytother Res. 2006 Sep;20(9):764-72. Analgesic, antiinflammatory and hypoglycaemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes (Zingiberaceae) in mice and rats. Ojewole JA. - J Med Food. 2005 Summer;8(2):149-53. Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes. Shen CL, Hong KJ, Kim SW Research showing ginger's benefits for mental performance Authorative studies Ayurvedic Pharmacology: Gogte p.314 Animal studies - Pharmacol Biochem Behav. 2006 Jun;84(2):179-88. Epub 2006 Jun 21.Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner. Haksar A, Sharma A, Chawla R, Kumar R, Arora R, Singh S, Prasad J, Gupta M, Tripathi RP, Arora MP, Islam F, Sharma RK. - Phytotherapy Re. 2002 Jun;16(4):312-5. Enhanced conditioned inhibitory avoidance by a combined extract of Zingiber officinale and Ginkgo biloba. Topic B, Hasenöhrl RU, Häcker R, Huston JP. - Neurobiol Aging. 2002 Jan-Feb;23(1):135-143. Enhanced maze performance and reduced oxidative stress by combined extracts of zingiber officinale and ginkgo biloba in the aged rat. Topic B, Tani E, Tsiakitzis K, Kourounakis PN, Dere E, Hasenöhrl RU, Häcker R, Mattern CM, Huston JP. - Phytother Res. 2002 Nov;16(7):621-6. Anxiolytic and antiemetic activity of Zingiber officinale. Vishwakarma SL, Pal SC, Kasture VS, Kasture SB. - Pharmacol Biochem Behav. 1998 Feb;59(2):527-35. Dissociation between anxiolytic and hypomnestic effects for combined extracts of zingiber officinale and ginkgo biloba, as opposed to diazepam. Hasenöhrl RU, Topic B, Frisch C, Häcker R, Mattern CM, Huston JP November 2001 Additional research on other factors Akoachere JF, Ndip RN, Chenwi EB et al. Antibacterial effect of Zingiber officinale and Garcinia kola on respiratory tract pathogens. East Afr Med J. 2002 Nov;79(11):588-92 2002. Bode A. Ginger is an effective inhibitor of HCT116 human colorectal carcinoma in vivo. paper presented at the Frontiers in Cancer Prevention Research Conference, Phoenix, AZ Ocbober 26-3-, 2003. Borrelli F, Capasso R, Aviello G, Pittler MH, Izzo AA. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol. 2005 Apr;105(4):849-56. PMID:15802416. Ficker CE, Arnason JT, Vindas PS et al. Inhibition of human pathogenic fungi by ethnobotanically selected plant extracts. Mycoses. 2003 Feb;46(1-2):29-37 2003. Fischer-Rasmussen W, Kjaer SK, Dahl C, et al. Ginger treatment of hypereesis gravidarum. Eur J Obstet Gynecol Reprod Biol 38(1990):19-24 1990. Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. [6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life Sci. 2003 Nov 14;73(26):3427-37. . Jagetia GC, Baliga MS, Venkatesh P, Ulloor JN. Influence of ginger rhizome (Zingiber officinale Rosc) on survival, glutathione and lipid peroxidation in mice after whole-body exposure to gamma radiation. Radiat Res. 2003 Nov;160(5):584-92. Kiuchi F, et al. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull 40 (1992):387-91 1992. Phan PV, Sohrabi A, Polotsky A, Hungerford DS, Lindmark L, Frondoza CG. Ginger extract components suppress induction of chemokine expression in human synoviocytes. J Altern Complement Med. 2005 Feb;11(1):149-54. PMID:15750374. Rhode JM, Huang J, Fogoros S, Tan L, Zick S, Liu JR. Ginger induces apoptosis and autophagocytosis in ovarian cancer cells. Abstract #4510, presented April 4, 2006 at the 97th AACR Annual Meeting, April 1-5, 2006, Washington, DC	Research home Herbal remedies Ginger herbal remedy
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